4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp

Title4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp
Publication TypeJournal Article
Year of Publication2017
AuthorsYang I., Yoon J., Kim D., Hahn D., Nam SJ, Fenical W
JournalTetrahedron Letters
Volume58
Pagination2322-2324
Date Published2017/06
Type of ArticleArticle
ISBN Number0040-4039
Accession NumberWOS:000403528100003
Keywords14-Membered macrolide; derivatives; Kromycin derivative; Marine-derived Streptomyces; narbomycin; Pikromycin aglycone; sp.; venezuelae; yc-17
Abstract

HPLC-UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data. (C) 2017 Published by Elsevier Ltd.

DOI10.1016/j.tetlet.2017.03.088
Short TitleTetrahedron Lett.
Student Publication: 
No
Research Topics: 
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