|Title||4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Yang I., Yoon J., Kim D., Hahn D., Nam SJ, Fenical W|
|Type of Article||Article|
|Keywords||14-Membered macrolide; derivatives; Kromycin derivative; Marine-derived Streptomyces; narbomycin; Pikromycin aglycone; sp.; venezuelae; yc-17|
HPLC-UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data. (C) 2017 Published by Elsevier Ltd.
|Short Title||Tetrahedron Lett.|