|Title||5-Hydroxycyclopenicillone, a New beta-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp HPQJ-34|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Fang F., Zhao J.Y, Ding L.J, Huang C.H, Naman C.B, He S., Wu B., Zhu P., Luo Q.J, Gerwick WH, Yan X.J, Wang Q.W, Zhang Z.J, Cui W.|
|Type of Article||Article|
|Keywords||Alzheimer's disease; alzheimers-disease; cyclopentenone; electronic circular-dichroism; marine; natural-products; optical-rotation; penicillium-citrinum; spectra; sponge-derived fungus; Trichoderma sp HPQJ-34|
A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease beta-amyloid (A beta) fibrillization in vitro. Moreover, 1 significantly reduced H2O2-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-A fi fibrillization properties and neuroprotective effects, and might be a good free radical scavenger.
|Short Title||Mar. Drugs|