5-Hydroxycyclopenicillone, a New beta-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp HPQJ-34

Title5-Hydroxycyclopenicillone, a New beta-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp HPQJ-34
Publication TypeJournal Article
Year of Publication2017
AuthorsFang F., Zhao J.Y, Ding L.J, Huang C.H, Naman C.B, He S., Wu B., Zhu P., Luo Q.J, Gerwick WH, Yan X.J, Wang Q.W, Zhang Z.J, Cui W.
JournalMarine Drugs
Volume15
Date Published2017/08
Type of ArticleArticle
ISBN Number1660-3397
Accession NumberWOS:000408763400025
KeywordsAlzheimer's disease; alzheimers-disease; cyclopentenone; electronic circular-dichroism; marine; natural-products; optical-rotation; penicillium-citrinum; spectra; sponge-derived fungus; Trichoderma sp HPQJ-34
Abstract

A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease beta-amyloid (A beta) fibrillization in vitro. Moreover, 1 significantly reduced H2O2-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-A fi fibrillization properties and neuroprotective effects, and might be a good free radical scavenger.

DOI10.3390/md15080260
Short TitleMar. Drugs
Student Publication: 
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