|Title||Actinobenzoquinoline and actinophenanthrolines a-c, unprecedented alkaloids from a marine actinobacterium|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Nam SJ, Kauffman CA, Jensen PR, Moore C.E, Rheingold A.L, Fenical W|
|Type of Article||Article|
|Keywords||1,10-phenanthroline; 1,7-phenanthroline; actinomycete; anthracycline; drug-metabolizing-enzymes; induction; inhibition; it-62-b; oltipraz; streptomyces sp|
Chemical investigation of a marine actinomycete within the family Streptomycetaceae (our strain CNQ-149) has led to the isolation of the unprecedented alkaloids, actinobenzoquinoline (1) and actinophenanthrolines A-C (2-4). The chemical structures of 1-4 were assigned by interpretation of NMR spectroscopic data, and their absolute configurations were assigned by X-ray analysis. Actinobenzoquinoline possesses a 5-methyloxazolidin-4-one moiety and a dihydrobento[h],quinoline core structure, while actinophenanthrolines A-C are composed of hydroxypropanamide-substituted 1,7-phenanthroline core skeletons.
|Short Title||Org. Lett.|