Actinoranone, a cytotoxic meroterpenoid of unprecedented structure from a marine adapted streptomyces sp

TitleActinoranone, a cytotoxic meroterpenoid of unprecedented structure from a marine adapted streptomyces sp
Publication TypeJournal Article
Year of Publication2013
AuthorsNam SJ, Kauffman CA, Paul L.A, Jensen PR, Fenical W
JournalOrganic Letters
Volume15
Pagination5400-5403
Date Published2013/11
Type of ArticleArticle
ISBN Number1523-7060
Accession NumberWOS:000326615100002
Keywordsactinomycete diversity; alcohols; bacterium; nmr; resource; sediments
Abstract

The isolation and structure elucidation of a new meroterpenoid, actinoranone (1), produced by a marine bacterium closely related to the genus Streptomyces is reported. Actinoranone is composed of an unprecedented dihydronaphthalenone polyketide linked to a bicyclic diterpenoid. The stereochemistry of 1 was defined by application of the advanced Mosher's method and by interpretation of spectroscopic data. Actinoranone (1) is significantly cytotoxic to HCT-116 human colon cancer cells with an LD50 = 2.0 mu g/mL.

DOI10.1021/ol402080s
Short TitleOrg. Lett.
Integrated Research Themes: 
Student Publication: 
No