|Title||Actinoranone, a cytotoxic meroterpenoid of unprecedented structure from a marine adapted streptomyces sp|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Nam SJ, Kauffman CA, Paul L.A, Jensen PR, Fenical W|
|Type of Article||Article|
|Keywords||actinomycete diversity; alcohols; bacterium; nmr; resource; sediments|
The isolation and structure elucidation of a new meroterpenoid, actinoranone (1), produced by a marine bacterium closely related to the genus Streptomyces is reported. Actinoranone is composed of an unprecedented dihydronaphthalenone polyketide linked to a bicyclic diterpenoid. The stereochemistry of 1 was defined by application of the advanced Mosher's method and by interpretation of spectroscopic data. Actinoranone (1) is significantly cytotoxic to HCT-116 human colon cancer cells with an LD50 = 2.0 mu g/mL.
|Short Title||Org. Lett.|