Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons

TitleAlkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons
Publication TypeJournal Article
Year of Publication2018
AuthorsHuang Q.L, Chen J., Zhang W.J, Zhou B.P, Zhang C.L, Gerwick WH, Cao Z.Y
JournalPhytochemistry
Volume150
Pagination85-92
Date Published2018/06
Type of ArticleArticle
ISBN Number0031-9422
Accession NumberWOS:000435623400009
Keywordsalkaloids; antiinflammatory activities; Biochemistry & Molecular Biology; ca2+ oscillations; cerebrocortical neurons; channels; Chemical correlation; Corydalis decumbens; epilepsy; excitability; inhibition; isoquinoline; medicinal-plants; Neuron; Plant Sciences; protopine; tetrahydropalmatine
Abstract

Eight previously undescribed alkaloids, named corydemine, dihydrocorydemine, corydedine, 8,13-dioxo-14-hydroxytetrahydropalmatine, egenine-alpha-N-oxide, egenine-beta-N-oxide, 7'-O-ethylegenine-alpha-N-oxide, and 7'-O-ethylegenine-beta-N-oxide, together with three known ones, muramine, L-tetrahydropalmatine, and (+)-egenine, were isolated from the bulbs of Corydalis decumbens. Their structures were elucidated by comprehensive spectroscopic analysis and chemical correlation. The isolated compounds were tested for their ability to modulate neuronal excitability in primary cultured neocortical neurons. Four of the compounds, corydemine, dihydrocorydemine, muramine, and L-tetrahydropalmatine, inhibited neuronal excitability with IC50 values of 3.6, 16.7, 13.5 and 14.0 mu M, respectively. (C) 2018 Elsevier Ltd. All rights reserved.

DOI10.1016/j.phytochem.2018.03.006
Short TitlePhytochemistry
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