Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patino, Darien

TitleAnalysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patino, Darien
Publication TypeJournal Article
Year of Publication2019
AuthorsTayler N.M, Boya C.A, Herrera L., Moy J., Ng M., Pineda L., Almanza A., Rosero S., Coronado L.M, Correa R., Santamaria R., Caballero Z., Durant-Archibold A.A, Currency K.JT, Balunas M.J, Gerwick WH, Spadafora A., Gutierrez M., SpadaforaId C.
JournalPlos One
Volume14
Date Published2019/04
Type of ArticleArticle
ISBN Number1932-6203
Accession NumberWOS:000462993900015
Keywordsdrug; in-vitro; parasites; Science & Technology - Other Topics
Abstract

Cocos nucifera (C. nucifera) (the coconut palm tree) has been traditionally used to fight a number of human diseases, but only a few studies have tested its components against parasites such as those that cause malaria. In this study, C. nucifera samples were collected from a private natural reserve in Punta Patino, Darien, Panama. The husk, leaves, pulp, and milk of C. nucifera were extracted and evaluated against the parasites that cause Chagas' disease or American trypanosomiasis (Trypanosoma cruzi), leishmaniasis (Leishmania donovani) and malaria (Plasmodium falciparum), as well as against a line of breast cancer cells. While there was no activity in the rest of the tests, five and fifteen-minute aqueous decoctions of leaves showed antiplasmodial activity at 10% v/v concentration. Removal of some HPLC fractions resulted in loss of activity, pointing to the presence of synergy between the components of the decoction. Chemical molecules were separated and identified using an ultra-performance liquid chromatography (UPLC) approach coupled to tandem mass spectrometry (LC-MS/MS) using atmospheric pressure chemical ionization quadrupole-time of flight mass spectrometry (APCI-Q-TOF-MS) and molecular networking analysis, revealing the presence of compounds including polyphenol, flavone, sterol, fatty acid and chlorophyll families, among others.

DOI10.1371/journal.pone.0214193
Student Publication: 
No
Research Topics: 
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