Ansalactams B-D illustrate further biosynthetic plasticity within the ansamycin pathway

TitleAnsalactams B-D illustrate further biosynthetic plasticity within the ansamycin pathway
Publication TypeJournal Article
Year of Publication2016
AuthorsLe T.C, Yang I., Yoon Y.J, Nam SJ, Fenical W
JournalOrganic Letters
Volume18
Pagination2256-2259
Date Published2016/05
Type of ArticleArticle
ISBN Number1523-7060
Accession NumberWOS:000375891700079
Keywordsbacteria; derivatives; discovery; diversity; marine; metabolites; sediments; transformation
Abstract

Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.

DOI10.1021/acs.orglett.6b00892
Short TitleOrg. Lett.
Student Publication: 
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