Anthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete

TitleAnthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete
Publication TypeJournal Article
Year of Publication2013
AuthorsJang KHwa, Nam S-J, Locke JB, Kauffman CA, Beatty DS, Paul LA, Fenical W
JournalAngewandte Chemie International Edition
Volume52
Pagination7822-7824
Date Published2013/06
ISBN Number1521-3773
Keywordsanthrax; antibiotics; bacillus anthracis; natural products; polyketides
Abstract

A new antibiotic, anthracimycin, produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

(See the full July 17, 2013 news release on this item: "Compound Discovered at Sea Shows Potency against Anthrax.")

DOI10.1002/anie.201302749
Student Publication: 
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