Biologically active new metabolites from a Florida collection of Moorea producens

TitleBiologically active new metabolites from a Florida collection of Moorea producens
Publication TypeJournal Article
Year of Publication2017
AuthorsSabry O.M, Goeger D.E, Gerwick WH
JournalNatural Product Research
Date Published2017/02
Type of ArticleArticle
ISBN Number1478-6419
Accession NumberWOS:000392628400009
Keywordsabsolute-configuration; amide; cyanobacterium lyngbya-majuscula; Cytotoxicity; floridamide; malyngamide; malyngamides; Moorea producens

A bioassay-guided investigation (cancer cell cytotoxicity) of a Moorea producens collection from Key West, Florida, led to the discovery of two new bioactive natural products [(+)-malyngamide Y and a cyclic depsipeptide, (+)-floridamide]. Their planar structures were deduced through extensive analysis of 1D and 2D NMR spectroscopic data and supported by HRFAB mass spectrometry. The new cyclic depsipeptide contains four amino acids units, including N- methyl phenylalanine, proline, valine and alanine, beside the unique unit, 2,2-dimethyl-3hydroxy- octanoic acid. In addition to the discovery of these two new compounds, two previously reported metabolites were also isolated and identified from this cyanobacterial collection; (-)-C-12 lyngbic acid and the antibacterial agent (-)-malyngolide.

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