Bissubvilides A and B, cembrane-capnosane heterodimers from the soft coral Sarcophyton subviride

TitleBissubvilides A and B, cembrane-capnosane heterodimers from the soft coral Sarcophyton subviride
Publication TypeJournal Article
Year of Publication2016
AuthorsSun P., Yu Q., Li J., Riccio R., Lauro G., Bifulco G., Kurtan T., Mandi A., Tang H., Li T.J, Zhuang C.L, Gerwick WH, Zhang W.
JournalJournal of Natural Products
Volume79
Pagination2552-2558
Date Published2016/10
Type of ArticleArticle
ISBN Number0163-3864
Accession NumberWOS:000386745300017
Keywordsabsolute-configuration; biscembranoids; circular-dichroism spectra; diterpenes; glaucum; inhibitors; nmr; Skeleton; tortuosum; trocheliophorum
Abstract

Two new biscembranoid-like compounds, bissubvilides A (1) and B (2), were isolated together with sarsolilide B (3), the proposed biogenetic precursor to 1, from the soft coral Sarcophyton subviride. The structures and absolute configurations were solved by spectroscopic analysis and TDDFT/ECD and DFT/NMR calculations. The bissubvilides represent a novel biscembranoid-like skeleton presumed to derive from a cembrane-type diene and a capnosane-type dienophile via a Diels-Alder reaction. These two molecules exerted no cytotoxicity against MG-63 or A549 tumor cells or HuH7 tumor stem cells.

DOI10.1021/acs.jnatprod.6b00453
Short TitleJ. Nat. Prod.
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