Briarane diterpenes from the South China Sea gorgonian coral, Junceella gemmacea

TitleBriarane diterpenes from the South China Sea gorgonian coral, Junceella gemmacea
Publication TypeJournal Article
Year of Publication2014
AuthorsZhou W., Li J., E H.C, Liu B.S, Tang H., Gerwick WH, Hua H.M, Zhang W.
JournalMarine Drugs
Volume12
Pagination589-600
Date Published2014/04
Type of ArticleArticle
ISBN Number1660-3397
Accession NumberWOS:000335745100023
Keywordsbriarane; dichotella-gemmacea; diterpenoid; ellisellidae; fragilis; genus junceella; growth; ii; Junceella gemmacea; junceellolide; natural-product chemistry; part
Abstract

Four new briarane diterpenoids, junceellolides M-P (1-4), were isolated together with seven known analogs (5-11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1-3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.

DOI10.3390/md12020589
Short TitleMar. Drugs
Integrated Research Themes: 
Student Publication: 
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