|Title||Briarane diterpenes from the South China Sea gorgonian coral, Junceella gemmacea|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Zhou W., Li J., E H.C, Liu B.S, Tang H., Gerwick WH, Hua H.M, Zhang W.|
|Type of Article||Article|
|Keywords||briarane; dichotella-gemmacea; diterpenoid; ellisellidae; fragilis; genus junceella; growth; ii; Junceella gemmacea; junceellolide; natural-product chemistry; part|
Four new briarane diterpenoids, junceellolides M-P (1-4), were isolated together with seven known analogs (5-11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1-3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.
|Short Title||Mar. Drugs|