Chlorizidine, a Cytotoxic 5H-Pyrrolo 2,1-a isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp

TitleChlorizidine, a Cytotoxic 5H-Pyrrolo 2,1-a isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp
Publication TypeJournal Article
Year of Publication2013
AuthorsAlvarez-Mico X, Jensen PR, Fenical W, Hughes CC
JournalOrganic Letters
Volume15
Pagination988-991
Date Published2013/03
Type of ArticleArticle
ISBN Number1523-7060
Accession NumberWOS:000315707400004
Keywordsantibiotics; derivatives; natural-products; nitrogen-heterocycles; pyoluteorin biosynthesis
Abstract

Cultivation of an obligate marine Streptomyces strain has provided the cytotoxic natural product chlorizidine A. X-ray crystallographic analysis revealed that the metabolite is composed of a chlorinated 2,3-dihydropyrrolizine ring attached to a chlorinated 5H-pyrrolo[2,1-a]isoindol-5-one. The carbon stereocenter in the dihydropyrrolizine is S-configured. Remarkably, the 5H-pyrrolo[2,1-a]isoindol-5-one moiety has no precedence in the field of natural products. The presence of this ring system, which was demonstrated to undergo facile nucleophilic substitution reactions at the activated carbonyl group, is essential to the molecule's cytotoxicity against HCT-116 human colon cancer cells.

DOI10.1021/ol303374e
Short TitleOrg. Lett.
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Student Publication: 
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