|Title||Cytotoxic halogenated monoterpenes from Plocamium cartilagineum|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Sabry O.MM, Goeger D.E, Valeriote F.A, Gerwick WH|
|Journal||Natural Product Research|
|Type of Article||Article|
|Keywords||halogenated monoterpenes; human; human colon cancers; human lung cancers; leukaemia; Plocamium cartilagineum; polyhalogenated monoterpenes; red alga; tumor-cell-lines|
As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(-)-(5E,7Z)-348-trichloro-7-dichloromethyl-3-methyl-157-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC50 4g/mL). Two of these compounds (3 and 4) were found to have cytotoxic activity in other cell line assays, especially against human leukaemia and human colon cancers (IC50 1.3g/mL). None of these metabolites were active as sodium channel blockers or activators. All structures were determined by spectroscopic methods (UV, IR, LRMS, HRMS, 1D NMR and 2D NMR). 1D and 2D NOE experiments were carried out on these compounds to confirm the geometry of the double bonds. [GRAPHICS] .