Cytotoxic halogenated monoterpenes from Plocamium cartilagineum

TitleCytotoxic halogenated monoterpenes from Plocamium cartilagineum
Publication TypeJournal Article
Year of Publication2017
AuthorsSabry O.MM, Goeger D.E, Valeriote F.A, Gerwick WH
JournalNatural Product Research
Date Published2017/01
Type of ArticleArticle
ISBN Number1478-6419
Accession NumberWOS:000389034600003
Keywordshalogenated monoterpenes; human; human colon cancers; human lung cancers; leukaemia; Plocamium cartilagineum; polyhalogenated monoterpenes; red alga; tumor-cell-lines

As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(-)-(5E,7Z)-348-trichloro-7-dichloromethyl-3-methyl-157-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC50 4g/mL). Two of these compounds (3 and 4) were found to have cytotoxic activity in other cell line assays, especially against human leukaemia and human colon cancers (IC50 1.3g/mL). None of these metabolites were active as sodium channel blockers or activators. All structures were determined by spectroscopic methods (UV, IR, LRMS, HRMS, 1D NMR and 2D NMR). 1D and 2D NOE experiments were carried out on these compounds to confirm the geometry of the double bonds. [GRAPHICS] .

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