Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

TitleDivergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin
Publication TypeJournal Article
Year of Publication2016
AuthorsLi Z.R, Li J., Gu J.P, Lai J.YH, Duggan BM, Zhang W.P, Li Z.L, Li Y.X, Tong R.B, Xu Y, Lin D.H, Moore BS, Qian PY
JournalNature Chemical Biology
Volume12
Pagination773-+
Date Published2016/10
Type of ArticleArticle
ISBN Number1552-4450
Accession NumberWOS:000384248600006
Keywordscells; cloning; colibactin biosynthesis; DNA; escherichia-coli; genotoxin; mechanism; pathway
Abstract

Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.

DOI10.1038/nchembio.2157
Short TitleNat. Chem. Biol.
Student Publication: 
No
Research Topics: 
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