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Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas

TitleDiversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas
Publication TypeJournal Article
Year of Publication2019
AuthorsBusch J., Agarwal V., Schorn M., Machado H., Moore BS, Rouse GW, Gram L., Jensen PR
Volume21
Pagination1575-1585
Date Published2019/05
Type of ArticleArticle
ISBN Number1462-2912
Accession NumberWOS:000471715900005
Keywordsbacterium; biosynthesis; diphenyl ethers pbdes; marine; microbiology; multiple sequence alignment; organic-compounds; thyroid-hormone; tool; vitamin-a
Abstract

The production of pentabromopseudilin and related brominated compounds by Pseudoalteromonas spp. has recently been linked to the bmp biosynthetic gene cluster. This study explored the distribution and evolutionary history of this gene cluster in the genus Pseudoalteromonas. A phylogeny of the genus revealed numerous clades that do not contain type strains, suggesting considerable species level diversity has yet to be described. Comparative genomics revealed four distinct versions of the gene cluster distributed among 19 of the 101 Pseudoalteromonas genomes examined. These were largely localized to the least inclusive clades containing the Pseudoalteromonas luteoviolacea and Pseudoalteromonas phenolica type strains and show clear evidence of gene and gene cluster loss in certain lineages. Bmp gene phylogeny is largely congruent with the Pseudoalteromonas species phylogeny, suggesting vertical inheritance within the genus. However, the gene cluster is found in three different genomic environments suggesting either chromosomal rearrangement or multiple acquisition events. Bmp conservation within certain lineages suggests the encoded products are highly relevant to the ecology of these bacteria.

DOI10.1111/1462-2920.14532
Student Publication: 
No
Research Topics: 
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