Dragocins A-D, structurally intriguing cytotoxic metabolites from a Panamanian marine cyanobacterium

TitleDragocins A-D, structurally intriguing cytotoxic metabolites from a Panamanian marine cyanobacterium
Publication TypeJournal Article
Year of Publication2019
AuthorsChoi H., Engene N, Byrum T., Hwang S., Oh D.C, Gerwick WH
JournalOrganic Letters
Volume21
Pagination266-270
Date Published2019/01
Type of ArticleArticle
ISBN Number1523-7060
Accession NumberWOS:000455285800057
Keywordschemistry; drug discovery
Abstract

Dragocins A-D (1-4) were isolated from a dark-red wooly textured marine cyanobacterium collected in Boca del Drago, Panama. Dragocins A-C (1-3) possessed 2,3-dihydroxypyrrolidine, 1-hydroxy-5-O-Me-benzoyl, and 4'-substituted-beta-ribofuranose moieties that connected to form a nine-membered macrocyclic ring. Dragocins A-C are members of a unique hybrid structural class with substitution at the C-4' position of a ribofuranose unit. Of the four new compounds, dragocin A was the most potent cytotoxin to human H-460 lung cancer cells

DOI10.1021/acs.orglett.8b03712
Short TitleOrg. Lett.
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