Drug Discovery from Marine Microbes

TitleDrug Discovery from Marine Microbes
Publication TypeJournal Article
Year of Publication2013
AuthorsGerwick WH, Fenner AM
JournalMicrobial Ecology
Volume65
Pagination800-806
Date Published2013/05
Type of ArticleReview
ISBN Number0095-3628
Accession NumberWOS:000318183800002
Keywordsagents; analog; dolastatin 10; ecteinascidia-turbinata; et-743; inhibitor; mechanism; phase-i; systems
Abstract

The marine environment has been a source of more than 20,000 inspirational natural products discovered over the past 50 years. From these efforts, 9 approved drugs and 12 current clinical trial agents have been discovered, either as natural products or as molecules inspired from the natural product structure. To a significant degree, these have come from collections of marine invertebrates largely obtained from shallow-water tropical ecosystems. However, there is a growing recognition that marine invertebrates are oftentimes populated with enormous quantities of "associated" or symbiotic microorganisms and that microorganisms are the true metabolic sources of these most valuable of marine natural products. Also, because of the inherently multidisciplinary nature of this field, a high degree of innovation is characteristic of marine natural product drug discovery efforts.

DOI10.1007/s00248-012-0169-9
Short TitleMicrob. Ecol.
Integrated Research Themes: