Enzymatic synthesis of polybrominated dioxins from the marine environment

TitleEnzymatic synthesis of polybrominated dioxins from the marine environment
Publication TypeJournal Article
Year of Publication2014
AuthorsAgarwal V., Moore BS
JournalAcs Chemical Biology
Volume9
Pagination1980-1984
Date Published2014/09
Type of ArticleArticle
ISBN Number1554-8929
Accession NumberWOS:000342121200011
Keywordsbiosynthesis; blue mussels; dibenzo-p-dioxins; diphenyl ethers; humans; inhibitors; origin; phenols; sponge dysidea-dendyi
Abstract

Polyhalogenated dibenzo-p-dioxins are arguably among the most toxic molecules known to man. In addition to anthropogenic sources, marine invertebrates also harbor polybrominated dibenzo-p-dioxins of as yet unknown biogenic origin. Here, we report that the bmp gene locus in marine bacteria, a recently characterized source of polybrominated diphenyl ethers, can also synthesize dibenzo-p-dioxins by employing different phenolic initiator molecules. Our findings also diversify the structural classes of diphenyl ethers accessed by the mmp biosynthetic pathway. This report lays the biochemical foundation of a likely biogenetic origin of dibenzo-p-dioxins present in the marine metabolome and greatly expands the toxicity potential of marine derived polyhaloganated natural products.

DOI10.1021/cb5004338
Short TitleACS Chem. Biol.
Integrated Research Themes: 
Student Publication: 
No
Research Topics: 
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