Eutypellenoids A-C, new pimarane diterpenes from the Arctic fungus Eutypella sp D-1

TitleEutypellenoids A-C, new pimarane diterpenes from the Arctic fungus Eutypella sp D-1
Publication TypeJournal Article
Year of Publication2018
AuthorsYu H.B, Wang X.L, Xu W.H, Zhang Y.X, Qian Y.S, Zhang J.P, Lu X.L, Liu X.Y
JournalMarine Drugs
Volume16
Date Published2018/08
Type of ArticleArticle
ISBN Number1660-3397
Accession NumberWOS:000442868200011
KeywordsArctic fungus; bioactivity; derivatives; Eutypella sp; Pharmacology & Pharmacy; pimarane diterpene; scoparia
Abstract

Three new pimarane diterpenes, eutypellenoids A-C (1-3), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 1-3 possessed an uncommon tetrahydrofuran-fused pimarane diterpene skeleton. The structures of all compounds were determined by detailed spectroscopic analysis, electronic circular dichroism (ECD) analysis, as well as a comparison with the literature data. Antibacterial, antifungal, and cytotoxic activities of these compounds were evaluated. Compound 2 displayed antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 8 and 8 mu g/mL, respectively. Additionally, compound 2 showed antifungal activity against Candida parapsilosis, Candida albicans, Candida glabrata, and Candida tropicalis with MIC values of 8, 8,16, and 32 mu g/mL, respectively. Furthermore, compound 2 exhibited moderate cytotoxic activity against HCT-116 cell line with IC50 value of 3.7 mu M.

DOI10.3390/md16080284
Short TitleMar. Drugs
Student Publication: 
No
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