Evolution of new characters after whole genome duplications: Insights from amphioxus

TitleEvolution of new characters after whole genome duplications: Insights from amphioxus
Publication TypeJournal Article
Year of Publication2013
AuthorsHolland LZ
JournalSeminars in Cell & Developmental Biology
Volume24
Pagination101-109
Date Published2013/02
Type of ArticleReview
ISBN Number1084-9521
Accession NumberWOS:000315681700004
KeywordsAlternative splicing; Amphioxus; basal chordate amphioxus; central-nervous-system; conserved; developmental expression; duplication; enhancers; epidermal sensory neurons; gene; hindbrain boundary; Midbrain/hindbrain boundary; Neural crest; neural crest evolution; neurogenic placodes; paired box; Placodes; region; transcription factors
Abstract

Additional copies of genes resulting from two whole genome duplications at the base of the vertebrates have been suggested as enabling the evolution of vertebrate-specific structures such as neural crest, a midbrain/hindbrain organizer and neurogenic placodes. These structures, however, did not evolve entirely de novo, but arose from tissues already present in an ancestral chordate. This review discusses the evolutionary history of co-option of old genes for new roles in vertebrate development as well as the relative contributions of changes in cis-regulation and in protein structure. Particular examples are the FoxD, FGF8/17/18 and Pax2/5/8 genes. Comparisons with invertebrate chordates (amphioxus and tunicates) paint a complex picture with co-option of genes into new structures occurring both after and before the whole genome duplications. In addition, while cis-regulatory changes are likely of primary importance in evolution of vertebrate-specific structures, changes in protein structure including alternative splicing are non-trivial. (C) 2012 Elsevier Ltd. All rights reserved.

DOI10.1016/j.semcdb.2012.12.007
Integrated Research Themes: 
Student Publication: 
No