Farnesides A and B, sesquiterpenoid nucleoside ethers from a marine-derived Streptomyces sp., strain CNT-372 from Fiji

TitleFarnesides A and B, sesquiterpenoid nucleoside ethers from a marine-derived Streptomyces sp., strain CNT-372 from Fiji
Publication TypeJournal Article
Year of Publication2013
AuthorsIlan E.Z, Torres M.R, Prudhomme J., Le Roch K., Jensen PR, Fenical W
JournalJournal of Natural Products
Volume76
Pagination1815-1818
Date Published2013/09
Type of ArticleArticle
ISBN Number0163-3864
Accession NumberWOS:000330331200040
Keywordsbacterium
Abstract

Famesides A and B (1, 2), linear sesquiterpenoids connected by ether links to a ribose dihydrouracil nucleoside, were isolated from a marine-derived Streptomyces sp., strain CNT-372, grown in saline liquid culture. The structures of the new compounds were assigned by comprehensive spectroscopic analysis primarily involving ID and 2D NMR analysis and by comparison of spectroscopic data to the recently reported ribose nucleoside JBIR-68 (3). The farnesides are only the second example of this exceedingly rare class of microbial terpenoid nucleoside metabolites. Farneside A (1) was found to have modest antimalarial activity against the parasite Plasmodium falciparum.

DOI10.1021/np400351t
Short TitleJ. Nat. Prod.
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