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Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

TitleFluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis
Publication TypeJournal Article
Year of Publication2018
AuthorsLeutou A.S, Yang I.H, Le T.C, Hahn D., Lim K.M, Nam SJ, Fenical W
JournalJournal of Antibiotics
Volume71
Pagination609-612
Date Published2018/06
Type of ArticleArticle
ISBN Number0021-8820
Accession NumberWOS:000433257100008
Keywordsactinomadura; b-1; biosynthesis; Biotechnology & Applied Microbiology; Immunology; influenza-a virus; microbiology; Pharmacology & Pharmacy
Abstract

A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

DOI10.1038/s41429-018-0033-3
Short TitleJ. Antibiot.
Student Publication: 
No
Research Topics: