|Title||Fucoxanthin, a Marine Carotenoid, Attenuates beta-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Lin JJ, Yu J., Zhao J.Y, Zhang K, Zheng J.C, Wang J.L, Huang C.H, Zhang J.R, Yan X.J, Gerwick WH, Wang Q.W, Cui W., He S.|
|Journal||Oxidative Medicine and Cellular Longevity|
|Type of Article||Article|
|Keywords||activation; alzheimers-disease; in-vitro; inflammation; inhibition; long-term potentiation; mechanisms; model; nf-kappa-b; oxidative; stress|
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers of beta-amyloid (A beta) are widely accepted as the main neurotoxins to induce oxidative stress and neuronal loss in AD. In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative stress properties, concentration dependently prevented A beta oligomer-induced increase of neuronal apoptosis and intracellular reactive oxygen species in SH-SY5Y cells. A beta oligomers inhibited the prosurvival phosphoinositide 3-kinase (PI3K)/Akt cascade and activated the proapoptotic extracellular signal-regulated kinase (ERK) pathway. Moreover, inhibitors of glycogen synthase kinase 3 beta (GSK3 beta) and mitogen-activated protein kinase (MEK) synergistically prevented A beta oligomer-induced neuronal death, suggesting that the PI3K/Akt and ERK pathways might be involved in A beta oligomer-induced neurotoxicity. Pretreatment with fucoxanthin significantly prevented A beta oligomer-induced alteration of the PI3K/Akt and ERK pathways. Furthermore, LY294002 and wortmannin, two PI3K inhibitors, abolished the neuroprotective effects of fucoxanthin against A beta oligomer-induced neurotoxicity. These results suggested that fucoxanthin might prevent A beta oligomer-induced neuronal loss and oxidative stress via the activation of the PI3K/Akt cascade as well as inhibition of the ERK pathway, indicating that further studies of fucoxanthin and related compounds might lead to a useful treatment of AD.