Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp

TitleGargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp
Publication TypeJournal Article
Year of Publication2015
AuthorsRho J.R, Subramaniam G., Choi H., Kim E.H, Ng S.P, Yoganathan K., Ng S., Buss A.D, Butler M.S, Gerwick WH
JournalOrganic Letters
Volume17
Pagination1377-1380
Date Published2015/03
Type of ArticleArticle
ISBN Number1523-7060
Accession NumberWOS:000351558100008
Keywordsabsolute; assignments; chiral solvents; configuration; creation; design; nmr databases; seca; small-molecule inhibitors; stereochemistry; structure elucidation
Abstract

Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishis universal NMR database.

DOI10.1021/acs.orglett.5b00068
Short TitleOrg. Lett.
Student Publication: 
No
Research Topics: 
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