|Title||Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Rho J.R, Subramaniam G., Choi H., Kim E.H, Ng S.P, Yoganathan K., Ng S., Buss A.D, Butler M.S, Gerwick WH|
|Type of Article||Article|
|Keywords||absolute; assignments; chiral solvents; configuration; creation; design; nmr databases; seca; small-molecule inhibitors; stereochemistry; structure elucidation|
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishis universal NMR database.
|Short Title||Org. Lett.|