Individual and joint effects of lead and mercury on acetylcholinesterase activity in goldfish brain

TitleIndividual and joint effects of lead and mercury on acetylcholinesterase activity in goldfish brain
Publication TypeJournal Article
Year of Publication2014
AuthorsYao K., Li Y., Zhu X.S, Zhu L.
JournalFresenius Environmental Bulletin
Volume23
Pagination2514-2519
Date Published2014/12
Type of ArticleArticle
ISBN Number1018-4619
Accession NumberWOS:000349805200020
Keywordsacetylcholinesterase; biomarker; cadmium; carassius-auratus; clam tapes-philippinarum; exposure; goldfish; inhibition; joint effects; lead; marine; mercury; methylmercury; system
Abstract

The combined effects of heavy metals, lead (Pb) and mercury (Hg), in the aquatic environment are not well understood. In this study, the individual and joint effects of Pb and Hg on brain Acetylcholinesterase (AChE EC 3.1.1.7) activity in goldfish (Carassius auratus) were investigated by a 28-day exposure. The results showed that individual Pb or Hg as well as their mixtures had significantly (p<0.05) effects on AChE activities in goldfish brain. However, no significant (p<0.05) inhibition of brain AChE activities in goldfish was found in all the treatments. The brain AChE activities of goldfish in both individual and joint groups were found to be increased initially, followed by a decrease to the normal level over time. It suggested that there may be an adaptation of the fish exposed to either the two individuals or their mixtures during a long-term exposure. In addition, the comparison between the individual and joint groups showed that the effects of mixture were different from those of individuals, suggesting a different action mechanism of mixtures in the joint effects of Pb and Hg. All these results could contribute to a better understanding of the combined effects of Pb and Hg on freshwater fish.

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