Introducing a novel mechanism to control heart rate in the ancestral Pacific hagfish

TitleIntroducing a novel mechanism to control heart rate in the ancestral Pacific hagfish
Publication TypeJournal Article
Year of Publication2016
AuthorsWilson C.M, Roa J.N, Cox G.K, Tresguerres M, Farrell A.P
JournalJournal of Experimental Biology
Volume219
Pagination3227-3236
Date Published2016/10
Type of ArticleArticle
ISBN Number0022-0949
Accession NumberWOS:000386834800009
Keywordsanoxia; Anoxia tolerance; bicarbonate; Bicarbonate ions; cAMP; Cardiac evolution; cardiac responses; cardiovascular-responses; crucian carp; eptatretus-cirrhatus; Heart rate control; myxine-glutinosa; production; sarcoplasmic-reticulum; Soluble adenylyl cyclase; soluble adenylyl-cyclase; systemic heart
Abstract

Although neural modulation of heart rate is well established among chordate animals, the Pacific hagfish (Eptatretus stoutii) lacks any cardiac innervation, yet it can increase its heart rate from the steady, depressed heart rate seen in prolonged anoxia to almost double its normal normoxic heart rate, an almost fourfold overall change during the 1-h recovery from anoxia. The present study sought mechanistic explanations for these regulatory changes in heart rate. We provide evidence for a bicarbonate-activated, soluble adenylyl cyclase (sAC)-dependent mechanism to control heart rate, a mechanism never previously implicated in chordate cardiac control.

DOI10.1242/jeb.138198
Short TitleJ. Exp. Biol.
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