Lipopeptides from the tropical marine cyanobacterium Symploca sp

TitleLipopeptides from the tropical marine cyanobacterium Symploca sp
Publication TypeJournal Article
Year of Publication2014
AuthorsMeyers E., Haeckl F.PJ, Boudreau P.D, Byrum T., Dorrestein PC, Valeriote F.A, Gerwick WH
JournalJournal of Natural Products
Volume77
Pagination969-975
Date Published2014/04
Type of ArticleArticle
ISBN Number0163-3864
Accession NumberWOS:000335127200032
Keywordscollection; cytotoxin; lyngbya-bouillonii cyanobacteria; macrolide; majuscula; metabolites; peptide; tasiamide
Abstract

A collection of the tropical marine cyanobacterium Symploca sp., collected near Kimbe Bay, Papua New Guinea, previously yielded several new metabolites including kimbeamides A-C, kimbelactone A, and tasihalide C. Investigations into a more polar cytotoxic fraction yielded three new lipopeptides, tasiamides C-E (1-3). The planar structures were deduced by 2D NMR spectroscopy and tandem mass spectrometry, and their absolute configurations were determined by a combination of Marfey's and chiral-phase GC-MS analysis. These new metabolites are similar to several previously isolated compounds, including tasiamide (4), grassystatins (5, 6), and symplocin A, all of which were isolated from similar filamentous marine cyanobacteria.

DOI10.1021/np401051z
Short TitleJ. Nat. Prod.
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