Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp

TitleLodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp
Publication TypeJournal Article
Year of Publication2017
AuthorsLe T.C, Yim C.Y, Park S., Katila N., Yang I., Song M.C, Yoon Y.J, Choi D.Y, Choi H., Nam SJ, Fenical W
JournalBioorganic & Medicinal Chemistry Letters
Date Published2017/07
Type of ArticleArticle
ISBN Number0960-894X
Accession NumberWOS:000404422000017
Keywordsalzheimers-disease; BACE1 inhibitor; future perspectives; Lodopyridone; Marine natural; metabolites; natural-products; products; resource; Saccharomonospora

HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A-C show weak inhibitory activities on the beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). (c) 2017 Elsevier Ltd. All rights reserved.

Short TitleBioorg. Med. Chem. Lett.
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