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Lytic to temperate switching of viral communities

TitleLytic to temperate switching of viral communities
Publication TypeJournal Article
Year of Publication2016
AuthorsKnowles B., Silveira C.B, Bailey B.A, Barott K., Cantu V.A, Cobian-Guemes A.G, Coutinho F.H, Dinsdale E.A, Felts B., Furby KA, George E.E, Green K.T, Gregoracci G.B, Haas AF, Haggerty J.M, Hester E.R, Hisakawa N., Kelly LW, Lim Y.W, Little M., Luque A., McDole-Somera T., McNair K., de Oliveira L.S, Quistad S.D, Robinett N.L, Sala E, Salamon P., Sanchez S.E, Sandin S., Silva G.GZ, Smith J., Sullivan C., Thompson C., Vermeij MJA, Youle M., Young C., Zgliczynski B., Brainard R., Edwards R.A, Nulton J., Thompson F., Rohwer F
Date Published2016/03
Type of ArticleArticle
ISBN Number0028-0836
Accession NumberWOS:000372701300032
Keywordsbacterial-viruses; coral-reefs; cystic-fibrosis; datasets; great-barrier-reef; life strategies; marine-bacteria; metagenomic; microbial communities; respiratory-tract; virus-like particles

Microbial viruses can control host abundances via density-dependent lytic predator-prey dynamics. Less clear is how temperate viruses, which coexist and replicate with their host, influence microbial communities. Here we show that virus-like particles are relatively less abundant at high host densities. This suggests suppressed lysis where established models predict lytic dynamics are favoured. Meta-analysis of published viral and microbial densities showed that this trend was widespread in diverse ecosystems ranging from soil to freshwater to human lungs. Experimental manipulations showed viral densities more consistent with temperate than lytic life cycles at increasing microbial abundance. An analysis of 24 coral reef viromes showed a relative increase in the abundance of hallmark genes encoded by temperate viruses with increased microbial abundance. Based on these four lines of evidence, we propose the Piggyback-the-Winner model wherein temperate dynamics become increasingly important in ecosystems with high microbial densities; thus 'more microbes, fewer viruses'.

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