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Mass spectrometry analysis of protonated marine natural product seriniquinone

TitleMass spectrometry analysis of protonated marine natural product seriniquinone
Publication TypeJournal Article
Year of Publication2018
Authorsda Silva R.M, Guaratini T., Jimenez P.C, Fenical W, Costa-Lotufo L.V, Vessecchi R., Lopes N.P
JournalJournal of the Brazilian Chemical Society
Date Published2018/05
Type of ArticleArticle
ISBN Number0103-5053
Accession NumberWOS:000427641700024
Keywordsatoms; cancer; chemistry; computational chemistry; density; dermcidin; drugs; electrospray ionization mass spectrometry; fragmentation; metabolism; quinones; Serinicoccus; seriniquinone

Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/MS), to be further applied in pharmacokinetics and metabolism studies. All the proposals herein were supported by computational chemistry.

Short TitleJ. Braz. Chem. Soc.
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