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Meroindenon and merochlorins E and F, antibacterial meroterpenoids from a marine-derived sediment bacterium of the genus Streptomyces

TitleMeroindenon and merochlorins E and F, antibacterial meroterpenoids from a marine-derived sediment bacterium of the genus Streptomyces
Publication TypeJournal Article
Year of Publication2019
AuthorsRyu M.J, Hwang S., Kim S, Yang I., Oh D.C, Nam SJ, Fenical W
Volume21
Pagination5779-5783
Date Published2019/08
Type of ArticleArticle
ISBN Number1523-7060
Accession NumberWOS:000480371600003
Keywordschemistry
Abstract

Meroterpenoids, meroindenon (1) and merochlorins E (2) and F (3), were isolated from a marine-derived bacterium belonging to the genus Streptomyces. Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds 1-3 possess a tetrahydroxynaphthalene core and a C-15-isoprene unit. Compounds 2 and 3 exhibited strong antibacterial activities against B. subtilis, K. rhizophila, and S. aureus, with a range of MIC values from 1 to 2 mu g/mL.

DOI10.1021/acs.orglett.9b01440
Student Publication: 
No
Research Topics: