|Title||Metal composition of fine particulate air pollution and acute changes in cardiorespiratory physiology|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||S C, R D, LM K, M M, K VRyswyk, J V, L L, P K, E T, R V, S W|
|Type of Article||Journal article|
Studying the physiologic effects of components of fine particulate mass (PM2.5) could contribute to a better understanding of the nature of toxicity of air pollution.
We examined the relation between acute changes in cardiovascular and respiratory function, and PM2.5-associated-metals.
Using generalized linear mixed models, daily changes in ambient PM2.5-associated metals were compared to daily changes in physiologic measures in 59 healthy subjects who spent 5-days near a steel plant and 5-days on a college campus.
Interquartile increases in calcium, cadmium, lead, strontium, tin, vanadium and zinc were associated with statistically significant increases in heart rate of 1-3 beats per minute, increases of 1-3 mmHg in blood pressure and/or lung function decreases of up to 4% for total lung capacity.
Metals contained in PM2.5 were found to be associated with acute changes in cardiovascular and respiratory physiology.