Mycoleptodiscins A and B, Cytotoxic Alkaloids from the Endophytic Fungus Mycoleptodiscus sp F0194

TitleMycoleptodiscins A and B, Cytotoxic Alkaloids from the Endophytic Fungus Mycoleptodiscus sp F0194
Publication TypeJournal Article
Year of Publication2013
AuthorsOrtega HE, Graupner PR, Asai Y, TenDyke K, Qiu DY, Shen YYC, Rios N, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L
JournalJournal of Natural Products
Volume76
Pagination741-744
Date Published2013/04
Type of ArticleArticle
ISBN Number0163-3864
Accession NumberWOS:000318264700038
Keywordsmetabolites; red pyrroloquinoline alkaloids
Abstract

Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC50 values in the range 0.60-0.78 mu M.

DOI10.1021/np300792t
Short TitleJ. Nat. Prod.
Integrated Research Themes: 
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