Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis

TitleNapyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis
Publication TypeJournal Article
Year of Publication2014
AuthorsFarnaes L., Coufal N.G, Kauffman CA, Rheingold A.L, DiPasquale A.G, Jensen PR, Fenical W
JournalJournal of Natural Products
Volume77
Pagination15-21
Date Published2014/01
Type of ArticleArticle
ISBN Number0163-3864
Accession NumberWOS:000330336800004
Keywordsantibacterial; antibiotics-sf2415; fermentation; physicochemical properties; Streptomyces; taxonomy
Abstract

The microbial production, isolation, and structure elucidation of four new napyradiomycin congeners (1-4) is reported. The structures of these compounds, which are new additions to the marine-derived meroterpenoids, were defined by comprehensive spectroscopic analysis and by X-ray crystallography. Using fluorescence-activated cell sorting (FACS) analysis, napyradiomycins 1-4 were observed to induce apoptosis in the colon adenocarcinoma cell line HCT-116, indicating the possibility of a specific biochemical target for this 1 class of cytotoxins.

DOI10.1021/np400466j
Short TitleJ. Nat. Prod.
Integrated Research Themes: 
Student Publication: 
No
sharknado