|Title||New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Gong J., Sun P., Jiang N., Riccio R., Lauro G., Bifulco G., Li T.J, Gerwick WH, Zhang W.|
|Type of Article||Article|
|Keywords||4-methylene sterols; absolute-configuration; macrolides; marine origin; secosteroids|
Swinhoeisterols A (1) and B (2), two novel sterols with an unprecedented 6/6/5/7 ring system, were isolated from the sponge Theonella swinhoei. The structures and absolute configurations were elucidated by spectroscopic analysis, X-ray single-crystal diffraction, modified Mosher's method, and TDDFT/ECD calculations. The cytotoxicity of these compounds toward A549 and MG-63 cells encourages studies on their potential target using an inverse virtual screening approach. The predicted inhibitor of h(p300) was corroborated by an in vitro biological test.
|Short Title||Org. Lett.|