Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp CNX037

TitleNocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp CNX037
Publication TypeJournal Article
Year of Publication2013
AuthorsWu ZC, Li SM, Nam SJ, Liu Z, Zhang CS
JournalJournal of Natural Products
Volume76
Pagination694-701
Date Published2013/04
Type of ArticleArticle
ISBN Number0163-3864
Accession NumberWOS:000318264700029
Keywordsa-c; antiinflammatory depsipeptides; ascidian lissoclinum-bistratum; cyanobacterium lyngbya-majuscula; cyclic; didemnum-molle; genus streptomyces; hexapeptides; kahalalide-f; multidrug-resistance; streptomyces sp
Abstract

Two new cyclic hexapeptides, nocardiamides A (1) and B (2), were isolated from the culture broth of marine-derived actinomycete CNX037 strain that was identified as a Nocardiopsis species. The planar structures of nocardiamides A (1) and B (2) were assigned on the basis of ID and 2D NMR and HRESIMS spectroscopic analyses. Their absolute configurations were deduced by the advanced Marfey's method and chiral-phase HPLC analysis. The challenge of locating two D- and one L-valine residue in 1 and 2 was accomplished by total synthesis using solid-phase peptide synthetic methods. Both 1 and 2 showed negligible antimicrobial activities against seven indicator strains and exhibited no cytotoxicity against HCT-116.

DOI10.1021/np400009a
Short TitleJ. Nat. Prod.
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