Nonlinear statistical data assimilation for HVCRA neurons in the avian song system

TitleNonlinear statistical data assimilation for HVCRA neurons in the avian song system
Publication TypeJournal Article
Year of Publication2016
AuthorsKadakia N., Armstrong E., Breen D., Morone U., Daou A., Margoliash D., Abarbanel H.DI
JournalBiological Cybernetics
Volume110
Pagination417-434
Date Published2016/12
Type of ArticleArticle
ISBN Number0340-1200
Accession NumberWOS:000392752900004
KeywordsData assimilation; dynamical estimation; dynamical systems; excitation; inhibition; Ion channel properties; models; neuron models; Neuronal dynamics; Parameter estimation; parameter-estimation; sequence generation; Song system; Spiking; variational-methods; voltage recordings; zebra finch
Abstract

With the goal of building a model of the HVC nucleus in the avian song system, we discuss in detail a model of HVCRA projection neurons comprised of a somatic compartment with fast Na+ and K+ currents and a dendritic compartment with slower Ca2+ dynamics. We show this model qualitatively exhibits many observed electrophysiological behaviors. We then show in numerical procedures how one can design and analyze feasible laboratory experiments that allow the estimation of all of the many parameters and unmeasured dynamical variables, given observations of the somatic voltage V-s(t) alone. A key to this procedure is to initially estimate the slow dynamics associated with Ca, blocking the fast Na and K variations, and then with the Ca parameters fixed estimate the fast Na and K dynamics. This separation of time scales provides a numerically robust method for completing the full neuron model, and the efficacy of the method is tested by prediction when observations are complete. The simulation provides a framework for the slice preparation experiments and illustrates the use of data assimilation methods for the design of those experiments.

DOI10.1007/s00422-016-0697-3
Short TitleBiol. Cybern.
Student Publication: 
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