Omics-based natural product discovery and the lexicon of genome mining

TitleOmics-based natural product discovery and the lexicon of genome mining
Publication TypeJournal Article
Year of Publication2017
AuthorsMachado H., Tuttle R.N, Jensen PR
JournalCurrent Opinion in Microbiology
Volume39
Pagination136-142
Date Published2017/10
Type of ArticleReview
ISBN Number1369-5274
Accession NumberWOS:000418392800020
KeywordsBiosynthetic gene clusters; drug discovery; global analysis; mass-spectrometry; molecular networking; myxococcus-xanthus; nonribosomal peptide; pathways; secondary metabolism; streptomyces-coelicolor
Abstract

Genome sequencing and the application of omic techniques are driving many important advances in the field of microbial natural products research. Despite these gains, there remain aspects of the natural product discovery pipeline where our knowledge remains poor. These include the extent to which biosynthetic gene clusters are transcriptionally active in native microbes, the temporal dynamics of transcription, translation, and natural product assembly, as well as the relationships between small molecule production and detection. Here we touch on a number of these concepts in the context of continuing efforts to unlock the natural product potential revealed in genome sequence data and discuss nomenclatural issues that warrant consideration as the field moves forward.

DOI10.1016/j.mib.2017.10.025
Short TitleCurr. Opin. Microbiol.
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