Polyhydroxy cyclohexanols from a Dendrodochium sp fungus associated with the sea cucumber Holothuria nobilis Selenka

TitlePolyhydroxy cyclohexanols from a Dendrodochium sp fungus associated with the sea cucumber Holothuria nobilis Selenka
Publication TypeJournal Article
Year of Publication2014
AuthorsXu D.X, Sun P., Kurtan T., Mandi A., Tang H., Liu B.S, Gerwick WH, Wang Z.W, Zhang W.
JournalJournal of Natural Products
Volume77
Pagination1179-1184
Date Published2014/05
Type of ArticleArticle
ISBN Number0163-3864
Accession NumberWOS:000336510700013
Keywordsabsolute-configuration; chemical-shifts; derivatives; endophytic fungus; glycosides; hydrocarbons; metabolites; nmr; palitantin
Abstract

Four cyclohexanol analogues, dendrodochols A-D (1-4), were isolated from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka collected from the South China Sea. The structures were elucidated by means of detailed spectroscopic analysis. The absolute configurations were assigned using a solution TDDFT/ECD calculation approach and the modified Mosher's method. In an in vitro bioassay, these compounds exhibited no growth inhibition activity against the A549 and MG63 cell lines. Dendrodochols 1 and 3 exhibited modest antifungal activity against Candida strains, Cryptococcus neoformans, and Trichophyton rubrum, whereas 2 and 4 showed no activity against the tested strains.

DOI10.1021/np500024r
Short TitleJ. Nat. Prod.
Integrated Research Themes: 
Student Publication: 
No