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Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis

TitleRan GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis
Publication TypeJournal Article
Year of Publication2018
AuthorsCoppola U., Caccavale F., Scelzo M., Holland N.D, Ristoratore F., D'Aniello S.
JournalPlos One
Date Published2018/10
Type of ArticleArticle
ISBN Number1932-6203
Accession NumberWOS:000446897200002
Keywordsevolution; expression; genome duplication; import; inhibition; melanoma; nuclear-protein; provides insights; ran/tc4; Science & Technology - Other Topics; transport factor

Ran (ras-related nuclear protein) is a small GTPase belonging to the RAS superfamily that is specialized in nuclear trafficking. Through different accessory proteins, Ran plays key roles in several processes including nuclear import-export, mitotic progression and spindle assembly. Consequently, Ran dysfunction has been linked to several human pathologies. This work illustrates the high degree of amino acid conservation of Ran orthologues across evolution, reflected in its conserved role in nuclear trafficking. Moreover, we studied the evolutionary scenario of the pre-metazoan genetic linkage between Ran and Stx, and we hypothesized that chromosomal proximity of these two genes across metazoans could be related to a regulatory logic or a functional linkage. We studied, for the first time, Ran expression during amphioxus development and reported its presence in the neural vesicle, mouth, gill slits and gut corresponding to body regions involved in active cell division.

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