Saccharomonopyrones A-C, New alpha-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp CNQ-490

TitleSaccharomonopyrones A-C, New alpha-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp CNQ-490
Publication TypeJournal Article
Year of Publication2017
AuthorsYim C.Y, Le T.C, Lee T.G, Yang I., Choi H., Lee J., Kang K.Y, Lee J.S, Lim K.M, Yee S.T, Kang H., Nam SJ, Fenical W
JournalMarine Drugs
Volume15
Date Published2017/08
Type of ArticleArticle
ISBN Number1660-3397
Accession NumberWOS:000408763400005
Keywordsactinomycete; alpha-pyrones; communication; derivatives; differentiation; genus; inhibitor; marine natural products; nocardiopsis; polyketide synthase; Saccharomonospora sp.; streptomyces sp; Yoshinone
Abstract

Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new ff-pyrones, saccharomonopyrones A-C (1-3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first ff -pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted alpha-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 mu M.

DOI10.3390/md15080239
Short TitleMar. Drugs
Student Publication: 
No
Research Topics: 
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