Saccharoquinoline, a cytotoxic alkaloidal meroterpenoid from marine-derived bacterium Saccharomonospora sp

TitleSaccharoquinoline, a cytotoxic alkaloidal meroterpenoid from marine-derived bacterium Saccharomonospora sp
Publication TypeJournal Article
Year of Publication2019
AuthorsLe T.C, Lee E.J, Lee J., Hong A., Yim C.Y, Yang I., Choi H., Chin J., Cho S.J, Ko J., Hwang H., Nam SJ, Fenical W
JournalMarine Drugs
Volume17
Date Published2019/02
Type of ArticleArticle
ISBN Number1660-3397
Accession NumberWOS:000460795500026
KeywordsCytotoxicity; Marine natural product; meroterpenoid; Pharmacology & Pharmacy; Saccharomonospora sp
Abstract

A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.

DOI10.3390/md17020098
Short TitleMar. Drugs
Student Publication: 
No
Research Topics: 
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