|Title||Saccharoquinoline, a cytotoxic alkaloidal meroterpenoid from marine-derived bacterium Saccharomonospora sp|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Le T.C, Lee E.J, Lee J., Hong A., Yim C.Y, Yang I., Choi H., Chin J., Cho S.J, Ko J., Hwang H., Nam SJ, Fenical W|
|Type of Article||Article|
|Keywords||Cytotoxicity; Marine natural product; meroterpenoid; Pharmacology & Pharmacy; Saccharomonospora sp|
A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.
|Short Title||Mar. Drugs|