Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

TitleSharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
Publication TypeJournal Article
Year of Publication2016
AuthorsWang M.X, Carver J.J, Phelan VV, Sanchez LM, Garg N., Peng Y., Nguyen D.D, Watrous J., Kapono C.A, Luzzatto-Knaan T. et al.
JournalNature Biotechnology
Volume34
Pagination828-837
Date Published2016/08
Type of ArticleArticle
ISBN Number1087-0156
Accession NumberWOS:000381339600019
Keywordsdereplication; discovery; gene-cluster; genome; identification; metabolomics; repository; resource; spectral database; technologies
Abstract

The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data.

DOI10.1038/nbt.3597
Short TitleNat. Biotechnol.
Student Publication: 
No
Research Topics: 
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