Spongosine production by a Vibrio harveyi strain sssociated with the sponge Tectitethya crypta

TitleSpongosine production by a Vibrio harveyi strain sssociated with the sponge Tectitethya crypta
Publication TypeJournal Article
Year of Publication2015
AuthorsBertin M.J, Schwartz S.L, Lee J., Korobeynikov A., Dorrestein PC, Gerwick L, Gerwick WH
JournalJournal of Natural Products
Volume78
Pagination493-499
Date Published2015/03
Type of ArticleArticle
ISBN Number0163-3864
Accession NumberWOS:000352033900020
Keywordsbacteria; biosynthesis; marine sponge; metabolites; molecular networking; reveals; theonella-swinhoei
Abstract

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides." Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.

DOI10.1021/np5009762
Short TitleJ. Nat. Prod.
Student Publication: 
No
Research Topics: 
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