Tolerance traits related to climate change resilience are independent and polygenic

TitleTolerance traits related to climate change resilience are independent and polygenic
Publication TypeJournal Article
Year of Publication2018
AuthorsHealy T.M, Brennan R.S, Whitehead A., Schulte P.M
JournalGlobal Change Biology
Volume24
Pagination5348-5360
Date Published2018/11
Type of ArticleArticle
ISBN Number1354-1013
Accession NumberWOS:000447760300028
Keywordsadaptation; association; Biodiversity & Conservation; Environmental Sciences & Ecology; evolutionary; fundulus-heteroclitus; genetic architecture; genome-wide association; genotype-phenotype; hypoxia tolerance; natural-populations; oxygen; random forest; temperature; temperature tolerance; Thermal tolerance; trout oncorhynchus-mykiss
Abstract

The resilience of organisms to climate change through adaptive evolution is dependent on the extent of genetically based variation in key phenotypic traits and the nature of genetic associations between them. For aquatic animals, upper thermal tolerance and hypoxia tolerance are likely to be a important determinants of sensitivity to climate change. To determine the genetic basis of these traits and to detect associations between them, we compared naturally occurring populations of two subspecies of Atlantic killifish, Fundulus heteroclitus, that differ in both thermal and hypoxia tolerance. Multilocus association mapping demonstrated that 47 and 35 single nucleotide polymorphisms (SNPs) explained 43.4% and 51.9% of variation in thermal and hypoxia tolerance, respectively, suggesting that genetic mechanisms underlie a substantial proportion of variation in each trait. However, no explanatory SNPs were shared between traits, and upper thermal tolerance varied approximately linearly with latitude, whereas hypoxia tolerance exhibited a steep phenotypic break across the contact zone between the subspecies. These results suggest that upper thermal tolerance and hypoxia tolerance are neither phenotypically correlated nor genetically associated, and thus that rates of adaptive change in these traits can be independently fine-tuned by natural selection. This modularity of important traits can underpin the evolvability of organisms to complex future environmental change.

DOI10.1111/gcb.14386
Short TitleGlob. Change Biol.
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