Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea

TitleUprolides N, O and P from the Panamanian Octocoral Eunicea succinea
Publication TypeJournal Article
Year of Publication2016
AuthorsTorres-Mendoza D., Gonzalez Y., Gomez-Reyes J.F, Guzman H.M, Lopez-Perez J.L, Gerwick WH, Fernandez P.L, Gutierrez M.
Date Published2016/06
Type of ArticleArticle
ISBN Number1420-3049
Accession NumberWOS:000378757600141
KeywordsAnti-inflammatory; caribbean gorgonian octocoral; cembranolide diterpenes; cembranolides; diterpenoids; Eunicea succinea; mammosa; uprolides

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1-3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages.

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