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The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

TitleThe value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Publication TypeJournal Article
Year of Publication2019
AuthorsMcAlpine J.B, Chen S.N, Kutateladze A., MacMillan J.B, Appendino G., Barison A., Beniddir M.A, Biavatti M.W, Bluml S., Boufridi A., Butler M.S, Capon R.J, Choi Y.H, Coppage D., Crews P., Crimmins M.T, Csete M., Dewapriya P., Egan J.M, Garson M.J, Genta-Jouve G., Gerwick WH, Gross H., Harper M.K, Hermanto P., Hook J.M, Hunter L., Jeannerat D., Ji N.Y, Johnson T.A, Kingston D.GI, Koshino H., Lee H.W, Lewin G., Li J., Linington RG, Liu M.M, McPhail K.L, Molinski T.F, Moore BS, Nam J.W, Neupane R.P, Niemitz M., Nuzillard J.M, Oberlies N.H, Ocampos F.MM, Pan G., Quinn R.J, Reddy D.S, Renault J.H, Rivera-Chavez J., Robien W., Saunders C.M, Schmidt T.J, Seger C., Shen B, Steinbeck C., Stuppner H., Sturm S., Taglialatela-Scafati O., Tantillo D.J, Verpoorte R., Wang B.G, Williams C.M, Williams P.G, Wist J., Yue J.M, Zhang C., Xu Z.R, Simmler C., Lankin D.C, Bisson J., Pauli G.F
JournalNatural Product Reports
Date Published2019/01
Type of ArticleReview
ISBN Number0265-0568
Accession NumberWOS:000457374500001
Keywordsa-type proanthocyanidins; Biochemistry & Molecular Biology; chemistry; coupling-constants; macrocyclic lactone antibiotics; marine sponge; monoterpenoid indole alkaloids; nuclear-magnetic-resonance; Pharmacology & Pharmacy; proposed structure; proton; structure elucidation; sulfur-containing amides; unprecedented carbon skeleton

With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of disseminating raw nuclear magnetic resonance (NMR) data, independently of, and in parallel with, classical publishing outlets. A comprehensive compilation of historic to present-day cases as well as contemporary and future applications show that addressing the urgent need for a repository of publicly accessible raw NMR data has the potential to transform natural products (NPs) and associated fields of chemical and biomedical research. The call for advancing open sharing mechanisms for raw data is intended to enhance the transparency of experimental protocols, augment the reproducibility of reported outcomes, including biological studies, become a regular component of responsible research, and thereby enrich the integrity of NP research and related fields.

Short TitleNat. Prod. Rep.
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