New Publication: Bicarbonate-sensing soluble adenylyl cyclase is present in the cell cytoplasm and nucleus of multiple shark tissues

 

 

Image: Leopard shark gill cells co-expressed with sAC (green) and VHA (red). Nuclei stained in blue. Scale bar = 20um. (Roa and Tresguerres, 2017).

It’s 2017 and we are are off to a good start! Our most recent publication investigates the localization of acid-base sensor sAC in various leopard shark tissues, and found it highly abundant in the cytoplasm of gill acid- and base-secreting cells. sAC was also found present in or around the necleus of gill, cornea, and rectal gland cells, suggesting sAC’s possible role in regulating gene expression. To the best of our knowledge, this is the first description of nuclear sAC in an aquatic organism.

 

 

Check out this open access publication below.

Roa, J.N., Tresguerres, M. 2017. Bicarbonate-sensing soluble adenylyl cyclase is present in the cell cytoplasm and nucleus of multiple shark tissues. Physiological Reports