A team led by William Fenical at Scripps Institution of Oceanography at UC San Diego has discovered a new chemical compound from an ocean microbe in a preliminary research finding that could one day set the stage for new treatments for anthrax and other ailments such as methicillin-resistant Staphylococcus aureus (MRSA).
As reported in the international edition of the German journal Angewandte Chemie, Scripps researcher Chris Kauffman in Fenical’s group first collected the microorganism that produces the compound in 2012 from sediments close to shore off Santa Barbara, Calif. Fenical’s team in the Scripps Center for Marine Biotechnology and Biomedicine, working in conjunction with San Diego-based Trius Therapeutics, used an analytical technique known as spectroscopy to decipher the unusual structure of a molecule from a microscopic species known as Streptomyces. Initial testing of the compound, which they named anthracimycin, revealed its potency as a killer of anthrax, the infectious disease often feared as a biological weapon, as well as MRSA.
“The real importance of this work is the fact that anthracimycin has a new and unique chemical structure,” said Fenical, who added that the finding is a basic research discovery, which could lead to testing and development, and eventually a drug. “The discovery of truly new antibiotic compounds is quite rare. This discovery adds to many previous discoveries that show that marine bacteria are genetically and chemically unique.”
The discovery provides the latest evidence that the oceans, and many of its unexplored regions, represent a vast resource for new materials that could one day treat a variety of diseases and illnesses. Fenical, a distinguished professor of oceanography and pharmaceutical science, helped found the field of marine biomedicine as a researcher at Scripps. He is a pioneer in discovering and identifying these novel compounds. His research has helped bring attention to the need for continued exploration of the ocean for science and society.
In addition to Fenical and Kauffman, coauthors of the paper include first-author Kyoung Jang, as well as Sang-Jip Nam, Deanna Beatty, and Lauren Paul of Scripps and Jeff Locke of Trius Therapeutics.
The National Institutes of Health and the Transformational Medical Technologies program of the Department of Defense Chemical and Biological Defense Program through the Defense Threat Reduction Agency supported the research.
Scripps Institution of Oceanography at the University of California, San Diego, is one of the oldest, largest, and most important centers for global science research and education in the world. Now in its second century of discovery, the scientific scope of the institution has grown to include biological, physical, chemical, geological, geophysical, and atmospheric studies of the earth as a system. Hundreds of research programs covering a wide range of scientific areas are under way today on every continent and in every ocean. The institution has a staff of more than 1,400 and annual expenditures of approximately $195 million from federal, state, and private sources. Scripps operates robotic networks and one of the largest U.S. academic fleets. Birch Aquarium at Scripps serves as the interpretive center of the institution and showcases Scripps research and a diverse array of marine life through exhibits and programming for more than 430,000 visitors each year. Learn more at scripps.ucsd.edu.
About UC San Diego
The University of California, San Diego is a student-centered, research-focused, service-oriented public institution that provides opportunity for all. Recognized as one of the top 15 research universities worldwide and born of a culture of collaboration, UC San Diego sparks discoveries that advance society, drive economic growth and positively impact the world. Our students, who learn from Nobel laureates, MacArthur Fellows and National Academy members, are committed to public service. For the sixth consecutive year, UC San Diego has been ranked first in the nation based on research, civic engagement and social mobility. We are one campus with multiple pillars of excellence, a top ten public university that is transforming lives, shaping new disciplines and advancing the frontiers of knowledge. Learn more at www.ucsd.edu.