Brian Nies
LCMS Specialist
Varian Inc.
Abstract: 3-D ion traps have been a part of the Liquid Chromatography Mass Spectrometry (LCMS) landscape for over a decade, providing multi-path mass spectrometry experiments (ms/ms or msn) for unknown screening and structure elucidation. Recent advances in ion trap LCMS features including Enhanced Charge Capacity (ECC) which extends the number of ions that can be simultaneously analyzed and electronic control of Atmospheric Pressure Ionization (API), which delivers optimum drying gas during gradient LC separations by controlling the temperature distribution throughout a complete analytical run have resulted in producing an overall increase in sensitivity and a reduction in background interference while lowering the ownership price threshold. These features facilitate the economical analysis of complex and thermally labile compounds, including pharmaceutical, natural products and their associated metabolites. This talk will discuss in detail these new advances and will give examples of this technology applied to the characterization of molecules derived from natural products.
About Brian Nies: Mr. Nies is a graduate of Rutgers College, New Brunswick, NJ and studied Environmental Applications of Mass Spectrometry with Dr. Peter Palmer at San Francisco State University where he received his Masters of Science. Mr. Nies has over a decade of Industrial and Government associated work in Mass Spectrometry (LC and GCMS) including: Ion source and Hybrid Mass Spectrometer Design, Biochemical Warfare Detection, Environmental, Toxicological and Forensic analysis.